Conakry is the capital and largest city of Guinea. A port city, it serves as the economic, financial, and cultural center of Guinea. Its population as of the 2014 Guinea census was 1,660,973.

The current population of Conakry is difficult to ascertain. However, the U.S. Department of State’s Bureau of African Affairs has estimated it at two million, accounting for one-sixth of the country’s entire population.

Gueckedou, also known as Guekedou, is a southern Guinea town near Sierra Leone’s and Liberian borders. It had a population of 79,140 in 1996 but has grown massively since the civil wars, and, as of 2008, it is estimated to be 221,715. It was a center of fighting during the Second Liberian Civil War and the Sierra Leone Civil War in 2000 and 2001.

Kissidougou is a city in southern Guinea. It is the capital of the Kissidougou Prefecture. Following intensified conflicts in Sierra Leone and Liberia during the fall and winter of 2000, many people from Guéckédou fled to Kissidougou and stayed.

Kissidougou Airport serves the town, and the Niandan river flows past the city.

Kankan is the largest city in Guinea in land area and the third largest in population, with a population of 1 980 130 people as of 2020. The city is located in eastern Guinea, about 555 kilometers east of the national capital Conakry.

The city is the capital and largest town of the Kankan Prefecture and of the Kankan Region. The population is largely from the Mande ethnic group.

Nzérékoré is the second-largest city in Guinea by population after the capital, Conakry, and the largest city in the Guinée forestière region of southeastern Guinea. The city is the capital of Nzérékoré Prefecture. Nzérékoré is a commercial and economic center located approximately 354 mi (570 km) southeast of Conakry.

It was the center of an uprising against French rule in 1911. It is now known as a market town for its silverwork.